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Bodybuilders are continually looking for ways to build muscle through increasing testosterone.

ZMA is fast becoming one of the most popular supplements to boost testosterone levels.

Testosterone supplements currently dominant the supplement industry so knowing which one to try can become confusing. This guide provides information to help you decide if ZMA will aid your training.

History of ZMA

In the 1970's, deficiencies in zinc and magnesium were found to prevent growth by reducing testosterone levels1. Over 60% of American men and women over 20 eat less than the recommended daily allowances of zinc and magnesium2. Recreational training increases the loss of zinc and magnesium, further increasing deficiency risk3.

ZMA is patented under the ZMA trademark, developed by Victor Conte and is a precise blend of zinc, magnesium and vitamin B6. ZMA has become one of the most popular testosterone supplements, due to support from athletes and scientific research.

What is ZMA?

What's in ZMA

ZMA contains:

  • 20-30mg zinc
  • 400-500mg magnesium
  • 10mg vitamin B6

ZMA is a patented zinc monomethionine aspartate, magnesium aspartate and vitamin B6 formula. ZMA is made from a precise ratio to increase anabolic hormones and improve strength4.

Zinc

Zinc is an essential mineral responsible for hundreds of enzyme functions. Zinc is found in enzymes responsible for cell replication and protein generation and therefore influences muscle growth5. Zinc also plays important roles in metabolism, antioxidant protection and immune function5,6. Meats, eggs and seafood contain high amounts of zinc.

Deficiencies in zinc and magnesium can lead to a decrease in testosterone and IGF-18.1010

Magnesium

Magnesium is an essential mineral needed for hundreds of reactions within the body. These include fat and protein metabolism, formation of energy producing ATP, the release of protein transporting insulin as well as immune and hormone function6. Magnesium has been shown to reduce cortisol levels which is significant as high levels have been associated with muscle breakdown7. Nuts, grains, beans, dark green vegetables, fish and meat provide a source of magnesium.

Vitamin B6

Vitamin B6 is responsible for the processing of amino acids within the muscle and is also needed to make hormones. When used in a supplement with zinc and magnesium its absorption is increased.

Effects of ZMA on performance

Male testosterone levels decrease with age due to reduced testicular secretion8. On average 60% of American men and women have less zinc and magnesium in their diet than they need2. Physical training increases zinc and magnesium loss, making you more susceptible to deficiencies3. Zinc and vitamin B6 are especially vulnerable to depletion after intense training.

When zinc was supplemented in deficient men, testosterone levels were significantly increased8

Dr Laura Brilla took a group of football players and supplemented their diets with ZMA for 8 weeks. At the end of the study free testosterone and IGF-1 was significantly increased4.

Magnesium supplementation has been shown to increase peak knee extension torque following a resistance training program compared to people who did not supplement9.

ZMA has been shown to:

  • Aid weight gain10
  • Increase anabolic hormones5
  • Increase strength4,9
  • Increase free testosterone levels4
  • Increase IGF-14,10
  • Reduced muscle breakdown5
  • Increase muscle mass
  • Improve quality of sleep that will aid recovery
  • Boost immune function11,12

Zinc and magnesium also have a significant role to play in antioxidant protection. Zinc and magnesium are structural components of antioxidants. Therefore ZMA will optimise antioxidant enzymes to reduce fatigue, muscle damage and exercise performance11.

How ZMA improves performance

What is IGF-1?

Insulin like growth factor-1 (IGF-1) controls the growth increasing effects of GH (growth hormone)10

Training reduces zinc and magnesium levels in athletes caused by higher sweat rates and/or inadequate intake. Deficiencies in zinc and magnesium can lead to a decrease in testosterone and IGF-18,10.

Studies have shown that testosterone levels are significantly correlated with zinc levels. When zinc intake was restricted in men, testosterone levels reduced. When zinc was supplemented in deficient men, testosterone levels were significantly increased8.

Animal studies show that a zinc deficient diet caused a 60% reduction in IGF-1 after 14 days10. A magnesium deficient diet also prevented weight gain by 83% and reduced IGF-1 by 44%10. ZMA optimizes zinc, magnesium and vitamin B6 levels in precise amounts to boost testosterone production.

How to use ZMA

ZMA should be taken on an empty stomach, typically before bedtime.

Types of ZMA

ZMA products typically supply 30-45 servings with each serving containing 2-3 capsules. Any brands that are fortified with other metals may decrease the uptake of zinc and magnesium thereby decreasing the effectiveness of your ZMA.

Average values of SNC's ZMA range are provided in figure 1:

Price per serving - £0.48
Vitamin B6 -
24mg (10mg-30mg)
Magnesium -
360mg (150mg-450mg)
Zinc -
24g (10mg-30mg)

Figure 1: SNC's ZMA product range

Values show the ingredient range and average values and typically price per serving.

Potential adverse effects of ZMA

The long term use of high doses of zinc is not recommended. Zinc in prolonged high doses can interfere with the absorption of other nutrients such as copper and can suppress the immune function.

ZMA FAQ

Is ZMA legal?

Absolutely yes. ZMA is not banned as the ingredients can be found in foods (although not in the ratio contained in ZMA).

Is ZMA better than using pro-hormones?

First and foremost pro-hormones are banned, ZMA is safe and legal. You do not have to cycle on ZMA and can be used by young athletes and women. Although not all research supports ZMA the majority suggests that ZMA is beneficial with non of the side effects associated with pro-hormones.

I heard calcium affects the action of ZMA, is this true?

Yes, calcium blocks the absorption of zinc. Therefore it is recommended that ZMA should be taken on an empty stomach. More importantly ZMA should not be taken with any calcium supplements

Other than training are there any other factors that make people more susceptible to zinc or magnesium deficiencies?

People who train regularly are at risk of zinc and magnesium deficiencies. This may be due to loss during sweating or inadequate amounts in the diet. In addition to this women tend to eat less zinc and magnesium6.

Can zinc really protect us from the common cold?

It is commonly believed that zinc plays a role in the protection of infections such as the common cold. The studies have shown unclear results, half showing that zinc was effective at preventing infection and half did not11. The general agreement is that zinc will not prevent your cold from developing but can reduce the duration and severity if taken within 24 hours of the onset11.

Who should read this article?

ZMA is effective at elevating anabolic muscle-building hormones, therefore ZMA can be used by anyone looking to optimize their diet to increase strength and gain weight.

ZMA is used by:

  • Bodybuilders
  • Weight lifters
  • Wrestlers
  • Strength sports
  • Track and field athletes
  • Heavy endurance trainers

Physical training increases zinc and magnesium loss, making you more susceptible to deficiencies3

Learn More
Zinc Matrix from Reflex Nutrition

Zinc Matrix
from Reflex Nutrition

New Zinc Matrix Complex has been designed to support healthy anabolic-hormone production (without the use of pro-hormones).

ZMS HP from EAS

ZMA HP
from EAS

EAS has developed ZMA HP, a cutting-edge mineral formula designed to help ensure your daily requirements for zinc and magnesium are covered.

Pro Zma
from Prolab Nutrition

A unique patent pending anabolic formula manufactured by a proprietary process containing highly bioavailable forms of zinc and magnesium.

The references are not here to confuse you. They simply show you the research papers that have been used in our 'eXpert Buyers Guides' to make sure you get the right information.

1. Schwartz, R., Woodcock, NA., Blakely, JD., Wang, FL., and Khairallah, EA (1970) Effects of magnesium deficiency in growing rats on synthesis of liver proteins and serum albumin. Journal of Nutrition. 100:123-128.

2. US department of Agriculture, Agricultural research services (1996) Continuing survey of food intakes by individuals 1994 and diet and health knowledge survey. Springfield, VA: US department of Commerce, National Technical Information service.

3. Singh, A., Failla, ML., and Deuster, PA (1994) Exercise induced changes in immune function: Effects of zinc supplementation. Journal of Applied Physiology. 76:2298-2303.

4. Brilla, LR., and Conte, V., Effects of Zinc-Magnesium (ZMA) Supplementation on Muscle Attributes of Football Players. Medicine and Science in Sport and Exercise 1999; 31-5.

5. Wilborn, CD., Kerksick, CM., Campbell, BI., Taylor, LW., Marcello, BM., Rasmussen, CJ., Greenwood, MC., Almada, A., and Kreider, RB (2004) Effects of Zinc Magnesium Aspartate (ZMA) Supplementation on Training Adaptations and Markers of Anabolism and Catabolism. Journal of the International Society of Sports Nutrition 1 (2): 12-20.

6. Lukaski., HC (2000) Magnesium, zinc, and chromium nutriture and physical activity. American Journal of Clinical Nutrition 72:585S-593S.

7. Golf, SW., Bender, S., and Gruttner, J (1998) On the significance of magnesium in extreme physical stress. Cardiovascular Drugs and Therapy. 12:197-202.

8. Prasad, AS., Mantzoros, CS., Beck, FWJ., Hess, JW., and Brewer, GJ (1996) Zinc status and serum testosterone levels of healthy adults. Nutrition 12 (5): 344-348.

9. Brilla, LR., and Harley, TF (1992) Effects of magnesium supplementation on strength training in humans Journal of the American College of Nutrition 11:326-329.

10. Dorup, I., Flyvbjerg, A., Everts, ME., and Torben, C (1991) Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies. British Journal of Nutrition 66 (3): 505-521.

11. Maughan, RJ., King, DS., and Lea, T (2004) Dietary Supplements. Journal of Sport Sciences. 22:95-113 .

12. Gleeson, M., Nieman, DC., and Pedersen, BK (2004) Exercise, nutrition and Immune function. Journal of Sport Sciences. 22:115-125.

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Always consult your own GP if you're in any way concerned about your health.