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Colchicine

Illustration

Colchicine reduces the inflammatory (swelling) response and pain in people with gout (high uric acid blood levels leading to painful accumulation of uric acid crystals in and around joints).

Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, a herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.

Beneficial May Be Beneficial: Depletion or interference—The medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them.

Beta-carotene*

Potassium*

Vitamin B12*
Check Check: Other—Before taking any of these supplements or eating any of these foods with your medication, read this article in full for details.

Sodium
Side effect reduction/prevention

None known
Supportive interaction

None known
Reduced drug absorption/bioavailability

None known
Adverse interaction

None known

An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.

Interactions with Dietary Supplements

Vitamin B12
Colchicine may interfere with vitamin B12 in the body. Research is inconsistent. Both colchicine and vitamin B12 deficiency are reported to cause neuropathies (disorders of the nervous system), but it remains unclear whether neuropathies caused by colchicine could be due to vitamin B12 depletion.1 2

Nutrient malabsorption
Colchicine has been associated with impaired absorption of beta-carotene, fat, lactose (milk sugar), potassium, and sodium.3

References

1. Palopoli JJ, Waxman J. Colchicine neuropathy or vitamin B12 deficiency neuropathy? N Engl J Med 1987;317:1290 [letter].

2. Kuncl RW et al. Colchicine neuropathy or vitamin B12 deficiency neuropathy? N Engl J Med 1987;317:1290–1 [letter].

3. Werbach MR. Foundations of Nutritional Medicine. Tarzana, CA: Third Line Press, 1997, 223–4 [review].