Beta-Glucan

Beta-glucan is a fibre-type complex sugar (polysaccharide) derived from the cell wall of baker’s yeast, oat and barley fibre, and many medicinal mushrooms, such as maitake. In their natural states, yeast and mushrooms contain a mixture of beta-1,3-glucan and beta-1,6-glucan. Oats and barley contain a mixture of beta-1,3-glucan and beta-1,4-glucan. In addition to purified beta-1,3-glucan from these sources, you may see products listed as beta-1,3/1,6-glucan in the case of yeast-derived products and as beta-1,3/1,4-glucan when derived from oats. Similar (if not identical) properties have been shown for beta-glucan-rich extracts and purified beta-glucan derived from oats, baker’s yeast, and mushrooms.

Where is it found?

Beta-glucan is found in the cell walls of many yeast and cereal fibres, such as oats, wheat, and barley. As a dietary supplement, beta-glucan is available in liquid form as well as in capsules and tablets.

Beta-glucan has been used in connection with the following conditions (refer to the individual health concern for complete information):

Science Ratings	Health Concerns
	High cholesterol
	Immune enhancement
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For a herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Who is likely to be deficient?

Because beta-glucan is not an essential nutrient, deficiencies do not occur.

How much is usually taken?

For lowering cholesterol levels, the amount of beta-glucan used in clinical trials has ranged from 2,900 to 15,000 mg per day. For enhancing immune function, an effective amount has not yet been determined due to the lack of studies in this application. However, manufacturers of beta-glucan products usually recommend between 50 and 1,000 mg daily (to be taken on an empty stomach), although some products contain as much as 500 mg per capsule.

Are there any side effects or interactions?

No side effects have been reported.

At the time of writing, there were no well-known drug interactions with beta-glucan.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires August 2007.