Ribose

Ribose is a type of sugar normally made in the body from glucose. Ribose plays important roles in the synthesis of RNA, DNA, and the energy-containing substance adenosine triphosphate (ATP).

Where is it found?

Ribose is present in small amounts in many foods of plant or animal origin.

Ribose has been used in connection with the following conditions (refer to the individual health concern for complete information):

Science Ratings	Health Concerns
	Angina
	Athletic performance
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For a herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Who is likely to be deficient?

Ribose is not an essential nutrient, therefore deficiencies do not occur.

How much is usually taken?

Sports supplement manufacturers recommend 1 to 10 grams per day of ribose.

Are there any side effects or interactions?

No known side effects have been reported from the use of ribose when consumed in amounts of less than 10 grams per day. Larger amounts may cause gastro-intestinal distress such as diarrhoea,¹ and may lower glucose levels,² although it is not known whether symptoms of hypoglycaemia might result.

At the time of writing, there were no well-known drug interactions with ribose.

References

1. Gross M, Reiter S, Zollner N. Metabolism of D-ribose administered continuously to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 1989;67:1205–13.

2. Gross M, Zollner N. Serum levels of glucose, insulin, and C-peptide during long-term D-ribose administration in man. Klin Wochenschr 1991;69:31–6.

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires August 2007.