Tocotrienols

Tocotrienols are members of the vitamin E family. Like vitamin E, tocotrienols are potent anti-oxidants against lipid peroxidation (the damaging of fats by oxidation).¹ ²

Where are they found?

Tocotrienols are found primarily in the oil fraction of rice bran, palm fruit, barley, and wheat germ. Supplemental sources of tocotrienols are derived from rice bran oil and palm oil distillates. Tocotrienol supplements are available in capsules and tablets.

Tocotrienols have been used in connection with the following conditions (refer to the individual health concern for complete information):

Science Ratings	Health Concerns
	Atherosclerosis
	High Cholesterol
	Stroke
Reliable and relatively consistent scientific data showing a substantial health benefit. Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit. For a herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support and/or minimal health benefit.

Who is likely to be deficient?

As it is not an essential nutrient, no deficiency state exists.

How much is usually taken?

The typical recommendation is 140 to 360 mg per day. Most studies have used 200 mg daily.

Are there any side effects or interactions?

No significant adverse effects have been reported with tocotrienols.³

Are there any drug interactions?
Certain medicines may interact with tocotrienols. Refer to drug interactions for a list of those medicines.

References

1. Kamal-Eldin A, Appelqvist LA. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids 1996;31:671–701 [review].

2. Kamat JP, Devasagayam TPA. Tocotrienols from palm oil as potent inhibitors of lipid peroxidation and protein oxidation in rat brain mitochondria. Neurosci Lett 1995;195:179–82.

3. Theriault A, Chao JT, Wang Q, et al. Tocotrienol: a review of its therapeutic potential. Clin Biochem 1999;32:309–19 [review].

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The information presented in Healthnotes is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or chemist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires August 2007.