Modern BCAA

New Rules For BCAA

We made it VERY clear to our R & D team – USPlabs Modern BCAA™ MUST be developed under these strict rules:

BCAA Ratio formulation with mTOR activation in mind

• Ultra-Micronized
• No Artificial Colors
• Natural, refreshing taste
• No L-GLN

Little Known muscle building Pathway - mTOR

If you've never heard of mTOR (and even if you have), listen up and listen good as this is one of THE most under-rated muscle building & protein synthesis pathways known to man…

And…chances are…you're not even coming close to maximizing its enormous potential…

mTOR (Mammalian Target of Rapamycin) is a large proline-directed serine-threonine protein kinase that's responsible for a wide range of physiologic and metabolic functions in several cell types, including both adipocytes (fat cells) and myocytes (muscle cells)…

Among its many roles, mTOR is responsible for hypertrophic growth (an increase in muscle cell size, for example), protein synthesis and tissue morphogenesis…

As a result, compounds which target the regulatory pathways of mTOR have been highly sought out for quite some time…

A wide range of data have suggested that amino acids are capable of directly regulating mTOR signaling pathways in skeletal muscle (1, 2, 3, 4), including the possibility that they activate some of the cell signaling elements upstream from mTOR in the insulin/growth factor signaling pathway…

Unlike Your Mom, mTOR DOES Play Favorites

However, this same data suggest that the amino-acid induced activation of mTOR signaling pathways is not uniform, and there is evidence that the mechanism of mTOR activation may be both tissue and amino acid specific (5, 6).

In particular, the amino acid leucine is indicated as being primarily responsible for the branched chain amino-acid induced activation of mTOR signaling pathways, and therefore mTOR's effect on protein turnover and synthesis (1 – 6).

This hypothesis has come about as studies have shown that most of the effects of amino acids on mTOR signaling are abolished by lowering the concentration of leucine, or increased by adding leucine and, to a lesser extent, the other branched-chained amino acids.

Leucine IS the Star…BUT…

In other words, leucine is the star, but it also must be mentioned that the other two BCAA's, isoleucine & valine, need to be present in order to maximize results…

8-1-1 BCAA Ratio

With the above in mind, we've formulated USPlabs Modern BCAA™ with an 8-1-1 leucine-isoleucine-valine ratio…

In terms of the leucine, the reasoning here is that, from a strictly technical standpoint, the data displays that only leucine and those other amino acids structurally related to leucine are responsible for the increase in mTOR commonly associated with BCAA supplementation.

Results & Value

As you know, many people are doubling, tripling, even quadrupling their dosage of BCAAs with a 2:1:1 & 4:1:1 bias in order to achieve better results…

Given the fact that leucine is most likely the amino acid responsible for this effect, particularly in skeletal muscle, having a formula with an 8:1:1 ratio eliminates the need for such increased dosing.

Effectively creating an enormous value in addition to the other benefits.

3 Man Enter – 1 Man Leave

The other issue here is amino acid transport and metabolism. All three of the branched chain amino acids – leucine, isoleucine and valine – compete for the same transport systems, and as a result, the presence of high concentrations of the other two branch-chained amino acids may lower intracellular levels of leucine…

…Obviously NOT what you want…

This is further compounded by the fact that, once ingested, leucine first fulfills other structural roles unrelated to protein metabolism prior to activating mTOR signaling pathways…

The result is that BCAA products with a 2:1:1 or 4:1:1 bias may actually counteract the muscle building effects from the product, as these substrates are pitted against one another to compete for metabolism.

8-1-1 Rocks

By increasing the "normal" ratio of leucine to the other two branched chain amino acids, we ensure two things:

• Double & mega dosing are unnecessary, as we have already doubled the component that is primarily responsible for the protein turnover and synthesis increases we see with BCAAs.
• Competitive metabolism between the amino acids will not lower leucine levels to the point that it is unable to regulate mTOR.

Simply put, a 2:1:1 or 4:1:1 bias, while effective, is by no means optimal for mTOR signaling pathway activation, and an increase in protein synthesis associated with it.

Ultra-Micronized

Let's be honest – when your uncle was rockin' his Zubaz & fannypack, he was drinking the same bulky BCAA's that you're drinking right now…

Sure, now there's instantized BCAA's – but they are incredibly expensive & made by using soy…

And I know you're tired of BCAA "floaties" and losing valuable product stuck to the side of the bottle…

That's why the BCAA's in USPlabs Modern BCAA™ utilize an advanced micronization process that produces an incredibly light & voluminous powder that mixes great!

Plus, USPlabs Modern BCAA™ will keep you on your game at the gym or at work – no BCAA moustache or stained teeth to worry about…

Are You Drinking Ammonia?

Everyone knows creatine can quickly turn to its waste byproduct creatinine when mixed in water…

So why doesn't anyone ever talk about what L-GLN can break down to?

Middle School Memories

Remember that nasty ammonia smell when your middle school custodian was washing the floors? You could just smell and taste the toxicity…

I distinctly remember walking into the locker room before Phys Ed class and the freshly-applied ammonia felt like it was eating away my eye-balls …

I think it's safe to say we all have similar memories…

No way you would ever drink that stuff, right?

WRONG!

That's if you've been drinking L-GLN…

L-GLN is known for its instability, in the dry state and especially in an aqueous solution (5,6).

The degradation products from L-GLN can be glutamic acid, ammonia and pyroglutamic acid, the latter two being potentially toxic (5-9).

What's worse is the longer it sits in water, the more degradation takes place!

Yuck!

Needless to say, that's why we made it a rule that L-GLN was not in the USPlabs Modern BCAA™ formula…

Instead, to assist with blood GLN pools, we've included a compound called Sustamine™…

Sustamine™

This particular product consists of a GLN dipeptide (L-alanyl-L-GLN), which is more stable and far more water soluble than regular L-GLN (1).

These physicochemical properties alone may provide greater effectiveness as compared to l-GLN. However, the presence of a unique intestinal transporter for the dipeptide may also allow for an increased amount of GLN to reach the bloodstream and into skeletal muscle as compared to regular free L-GLN (2-4).

These notions are supported by the higher GLN concentrations in plasma and skeletal muscle of animal models administered alanyl-GLN, as compared to those observed with free L-GLN (3,4).

This is important because up to 65% of regular L-GLN can be destroyed before it makes its way to your muscles…

Would You Step Over a £20 Note To Pick Up A Penny?

As mentioned, we added Sustamine to assist with blood GLN pools, but I want to make it abundantly clear we're not trying to win GLN product of the year here…

USPlabs Modern BCAA™ is a BCAA formula first & foremost because, quite frankly, that's what delivers the goods…

If you want a bunch of ingredients that really won't have a significant impact on your physique & performance, then USPlabs Modern BCAA™ probably isn't for you…

I mean, why run a 6 yard draw when you can hit a 60 yard bomb over the top?

If you want an awesome BCAA product designed for those who truly realize just how important BCAA's are, then USPlabs Modern BCAA™ was made with you in mind.

Unbelievable Taste

Yes, I know, you've heard that one before – only to be disappointed…

And while taste is highly subjective, I'm incredibly confident you simply won't believe you're drinking a naturally flavored BCAA product…

You'll want to drink it all day long!